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Current Research

 

Advances in medicine can only be made through scientific research. Modern medicine is also becoming increasingly complex with numerous treatment options available for different conditions, so it is important that doctors are able to stay up to date with the latest research so they can assess what is best for their patients. 

 

Marc has dedicated his career to not only looking after patients but also conducting pioneering research to improve patient care and outcomes following surgery. He received special research training within the NIHR integrated academic training programme following completion of 3 years of dedicated research into bowel problems that received prestigious funding from the Royal College of Surgeons, and was recognised by the award of the highest degree; a PhD. 

 

He is recognised as an international expert in bowel and pelvic floor disorders and has over 15 years experience writing textbooks and book chapters and published manuscripts in medical journals. Currently, Professor Gladman leads a research group that is undertaking ground-breaking research focused at:

 

  1. "Understanding Bowel Function in Health and Disease" and applying such knowledge to improve the treatment of bowel problems. 

  2. “Improving the Care of the Surgical patient” by investigating what happens to patients after bowel surgery 

 

He supervises PhD, MPhil and MS students at the University of Sydney and has collaborations with the Menzies Centre for Health Policy in Sydney, the Centre for Health Outcomes & Policy, University of Michigan, USA and the Karolinska Institute in Sweden.

 

 

Latest Research

 

1 in 8 people living in the community suffer with loss of bowel control

 

An analysis by Prof Gladman's team of all the research conducted around the world has revealed that faecal incontinence affects almost 1 in 8 people living in the community  

 

 

 

 

 

 

 

 

 

 

Loss of bowel control affects 1 in 10 people in Sydney 

 

A landmark study led by Prof Gladman shows that loss of bowel control affects more than 1 in 10 people in Sydney

 

 

 

 

 

 

 

 

Sacral Neuromodulation improves bowel control in 8 out of 10 patients 

 

An analysis by Prof Gladman's team looking at all the research relating to Sacral Neuromodulation has shown that it successfully improves bowel control in approximately 8 in 10 patients with faecal incontinence  

 

 

 

 

 

 

 

 

 

 

 

1 in 12 people in Sydney have problems emptying their bowels 

 

A landmark study led by Prof Gladman shows that more than 1 in 12 people in Sydney have problems emptying their bowels

 

 

 

 

 

 

 

 

 

What can be done for sufferers of bowel problems with surgery 

 

Prof Gladman has provided a summary of the treatment options for sufferers of bowel problems

 

 

 

 

 

 

 



 

 

 

 

 

 

 

Key-hole surgery for colorectal cancer 

 

Prof Gladman provides expert comment on the latest research studies

Professor Gladman's Published Textbooks

 
  • Examination Surgery: A guide to passing the FRACS examination in general surgery. Young CJY, Gladman MA.  

       Elsevier, Australia 2013.

 

  • Clinical cases and OSCEs in surgery: the definitive guide to passing examinations. Ramachandran M, Gladman MA  Elsevier - 2Ed Churchill Livingstone, London 2010; 3Ed 2018.

 

  • The Secrets of Success: Getting into Specialty Training. Ramachandran M, Smith PJ, Gladman MA (Eds). 

       Hodder Education, London 2009.

 

  • The Secrets of Success: Getting into Medical School. Mahalingasivam V, Gladman MA, Ramachandran M (Eds). 

       Hodder Education, London 2009.

 

  • Crash Course Self-Assessment in Medicine and Surgery.  Ballinger A, Gladman MA (Faculty Eds) for: Sharma N. Elsevier - Mosby, London 2009.

 

  • The Secrets of Success: Getting into Foundation Training. Gladman MA, Ramachandran M, Portou MJ (Eds).  

       Hodder Education, London 2008.

 

  • Clinical Problem Solving EMQs Gladman MA. Last Minute MRCS

       PasTest, London 2006.

 

  • Intercollegiate MRCS: Clinical Problem Solving EMQs Volume 2. Knowles CH, Gladman MA, Dench JE, Hammond T, Khullar N, Gooneratne M PasTest, London 2005.

 

Professor Gladman's Published Book Chapters

 
  • Gladman MA, Scott SM, Williams NS. Assessing the Patient with Fecal Incontinence: An Overview, In: Zbar AP, Pescatori M, Wexner SD (eds). Complex Anorectal Disorders – Investigation and Management. UK: Springer-Verlag, 2005: 547-594.

 

  • Gladman MA, Scott SM, Williams NS. Antegrade Continent Colonic Conduit In: Duthie GS, Wexner SD (eds). Constipation: Aetiology, Evaluation and Management. UK: Springer-Verlag, 2006: 211-219. 

 

  • Scott SM, Gladman MA. Manometric, sensorimotor and neurophysiological evaluation of anorectal function. In: Rao SS (ed). Disorders of the Anorectum and Pelvic Floor. USA: WB Saunders, 2008: 511-538.

 

  • Gladman MA, Knowles CH. Surgical treatment of constipation and fecal incontinence. In: Rao SS (ed). Disorders of the Anorectum and Pelvic Floor. USA: WB Saunders, 2008: 605-25.

 

  • Portou MJ, Ramachandran M, Gladman MA. The Application Process for The Foundation Programme. In: Gladman MA, Ramachandran M, Portou MJ (Eds). The Secrets of Success: Getting into Foundation Training. Hodder Education, London 2008: 31-40.

 

  • Gladman MA, Ramachandran M, Portou MJ. Creating a Winning Application. In: Gladman MA, Ramachandran M, Portou MJ (Eds). The Secrets of Success: Getting into Foundation Training. Hodder Education, London 2008: 41-52.

 

  • Portou MJ, Ramachandran M, Gladman MA. Non-academic Achievements. In: Gladman MA, Ramachandran M, Portou MJ (Eds). The Secrets of Success: Getting into Foundation Training. Hodder Education, London 2008: 61-70.

 

  • Portou MJ, Ramachandran M, Gladman MA. The Patient as the Central Focus of Care. In: Gladman MA, Ramachandran M, Portou MJ (Eds). The Secrets of Success: Getting into Foundation Training. Hodder Education, London 2008: 131-142.

 

  • Smith PJ, Ramachandran M, Gladman MA. Specialty training across the specialties. In: Smith PJ, Ramachandran M, Gladman MA (Eds). The Secrets of Success: Getting into Specialty Training. Hodder Education, London 2009: 7-14.

 

  • Smith PJ, Ramachandran M, Gladman MA. Dissecting the application process. In: Smith PJ, Ramachandran M, Gladman MA (Eds). The Secrets of Success: Getting into Specialty Training. Hodder Education, London 2009: 23-27.

 

  • Gladman MA, Ramachandran M. How to get THAT job: an insider’s guide. In: Smith PJ, Ramachandran M, Gladman MA (Eds). The Secrets of Success: Getting into Specialty Training. Hodder Education, London 2009: 28-44.

 

  • Owen EA, Gladman MA. Audit and Research. In: Smith PJ, Ramachandran M, Gladman MA (Eds). The Secrets of Success: Getting into Specialty Training. Hodder Education, London 2009: 62-72.

 

  • Manak K, Crofts M, Gladman MA. Professional integrity. In: Smith PJ, Ramachandran M, Gladman MA (Eds). The Secrets of Success: Getting into Specialty Training. Hodder Education, London 2009: 78-85.

 

  • Ramachandran M, Gladman MA. Getting ready for the interview. In: Smith PJ, Ramachandran M, Gladman MA (Eds). The Secrets of Success: Getting into Specialty Training. Hodder Education, London 2009: 120-129.

 

  • Smith PS, Owen EA, Portou MJ, Ramachandran M, Gladman MA. Generic interview questions. In: Smith PJ, Owen EA, Portou J, Ramachandran M, Gladman MA (Eds). The Secrets of Success: Getting into Specialty Training. Hodder Education, London 2009: 130-156.

 

  • Gladman MA. Core surgical training. In: Smith PJ, Ramachandran M, Gladman MA (Eds). The Secrets of Success: Getting into Specialty Training. Hodder Education, London 2009: 167-179.

 

  • Scott SM, Gladman MA. Rectal barostat for sensory testing. In: Parkman HP, McCallum RW, Rao SSC, eds. Gastrointestinal Motility Testing: Laboratory and Office Handbook. SLACK Incorporated, New Jersey, USA 2011: 209-222

 

  • Gladman MA, Williams NS. Managing the megarectum. In: Zbar AP, Madof RD, Wexner SD (eds). Reconstructive Surgery of the Rectum, Anus and Perineum. Spinger,  UK, 2013: 283-296.

 

  • Gladman MA, Williams NS. Vertical reduction rectoplasty. In: O’Connell R, Madoff R, Soloman M (eds). Robb & Smith’s Operative Surgery of the Colon, Rectum and Anus 6E. UK: CRC Press, 2015: 665-671. 

 

  • Gladman MA. Idiopathic Megacolon and Megarectum. In Keighley MRB & Williams NS (eds). Surgery of the Anus, Rectum and Colon 4th Edition 2017 (in press).   

  • Ng KS, Gladman MA. Faecal Incontinence: Patient Assessment and Investigation. In: Devesa M (ed). Managing Anal Incontinence:  Pertinax Publishing 2017 (in press).  

 

 

Professor Gladman's Publications in Scientific Medical Journals

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  • Ng KS, Nassar N, Soares D, Stewart P, Gladman MA. Acute lower gastrointestinal hemorrhage: outcomes and risk factors for intervention in 949 emergency cases.  Int J Colorectal Dis 2017 DOI: 10.1007/s00384-017-2844-2 [Epub ahead of print].

  • Sirimanna PV, Gladman MA. Development of a proficiency-based virtual reality simulation training curriculum for laparoscopic appendicectomy ANZ J Surg 2017 June 12 DOI: 10.1111/ans.14135  [Epub ahead of print].

  • Mirbagheri N, Hatton S, Ng KS, Lagolopoulos J & Gladman MA. ‘Brain Responses to Mechanical Rectal Stimuli in Patients with Faecal Incontinence- an fMRI Study’. Colorectal Dis 2017 DOI: 10.1111/codi.13694 (in press) 

  • Ng KS, Brookes SJ, Montes-Adrian NA, Mahns DA, Gladman MA. First in Man: electrophysiological characterisation of human rectal afferents. Am J Physio – Gastro Liver 2016; 311: G1047-G1055

  • Boyce S, Nassar N, Alzahrani S, Suen M, Lee Y, Gladman MA. Young-onset colorectal cancer in New South Wales, Australia: a population-based study. MJA 2016; 205: 465-470. 

  • Mirbagheri N, Dunn G, Naganathan V, Suen M & Gladman MA. ‘Normal Values and Clinical Utility of Bedside Sonographic Assessment of Postoperative Gastric Emptying: A Prospective Cohort Study’. Dis Colon Rectum 2016; 59: 758-65.

  • Whiteley I, Russell M, Nassar N, Gladman MA. Outcomes of Support Rod Usage in Loop Stoma Formation. Int J Colorectal Dis 2016; 31: 1189-95.

  • Mirbagheri N, Sivakumaran Y, Nassar N, Gladman MA. Systematic Review of the Impact of Sacral Neuromodulation on Clinical Symptoms and Gastrointestinal Physiology. ANZ J Surg 2016; 86: 232-6.

  • Ng KS, Sivakumaran Y, Nassar N, Gladman MA. Prevalence of and factors associated with faecal incontinence in the community: a systematic review. Dis Colon Rectum 2015; 58:1194-2209.

  • Ng KS, Nassar N, Hamd K, Nagarajah A, Gladman MA. Prevalence of Functional Bowel Disorders and Faecal Incontinence: an Australian Primary-Care Survey. Colorectal Dis 2015; 17: 150-9. 

  • Windsor J, Searle J, Hanney R, Chapman A, Grigg MJ, Choong P, Mackay A, Smithers BM, Carney S, Smith JA, Wainer Z, Talley NJ, Gladman MA.Building a sustainable clinical academic workforce to meet the future healthcare needs of Australia and New Zealand: report from the first summit meeting. Intern Med J 2015; 45: 965-71.

  • Ng KS, Stewart P, Gladman MA. Post-operative lower GI haemorrhage following bowel resection. ANZ J Surg 2014 Jul 16. doi: 10.1111/ans.12766. [Epub ahead of print]

  • Windsor J, Searle J, Garrod TJ, Hanney R, Grigg MJ, Smith JA, Gladman MA. Developing an integrated training pathway for clinical academics: notes from the first bi-national summit meeting. ANZ J Surg 2015; 85: 398–399

  • Palit S, Bhan C, Lunniss PJ, Boyle DJ, Gladman MA, Knowles CH, Scott SM. Evacuation proctography: a reappraisal of normal variability. Colorectal Dis 2014; 16: 538-46

  • Wright DB, Ng KS, Keshava A, Gladman MA. An Unusual Cause of Large Bowel Obstruction. Colorectal Dis 2013; 15: e60-1.

  • Ng KS, Stewart P, Gladman MA. An uncommon site for a common lesion. ANZ J Surg 2013; 83: 88-9.

  • Sharma N, Patel M, Gladman MA, Ahmed S, Dorudi S. Not one, but two unexpected findings in a 19-year-old man. Lancet 2010; 375: 1664.

  • Brookes SJ, Dinning PG, Gladman MA. Neuroanatomy and physiology of colorectal function and defaecation: from basic science to human clinical studies. Neurogastroenterol Motil 2009; 21 (s2): 9-19.

  • Lunniss PJ, Gladman MA, Benninga MA, Rao SS. Pathophysiology of rectal evacuatory dysfunction. Neurogastroenterol Motil 2009; 21 (s2): 31-44.

  • Sharma N, Gladman MA, Ahmed S. Idiopathic necrotising fasciitis. BMJ Case Reports 2009 [doi:10.1136/bcr.09.2008.0924]

  • Gladman MA, Aziz Q, Scott SM, Williams NS, Lunniss PJ. Rectal hyposensitivity: pathophysiologic mechanisms. Neurogastroenterol Motil 2009; 21: 508-16.

  • Gladman MA, Haq AI, Davies TW. The syringe test to determine the integrity of intestinal anastomoses. Ann R Coll Surg Engl 2008; 90: 696-697.

  • Scott SM, Gladman MA. Manometric, sensorimotor and neurophysiological evaluation of anorectal function. Gastroenterol Clin North Am 2008; 37: 511-538.

  • Gladman MA, Knowles CH. Surgical treatment of constipation and fecal incontinence. Gastroenterol Clin North Am 2008; 37: 605-25.

  • Zarate N, Knowles CH, Newell M, Garvie NW, Gladman MA, Lunniss PJ, Scott SM. In patients with slow transit constipation, the pattern of colonic transit delay does not differentiate between those with or without impaired rectal evacuation. Am J Gastroenterol 2008; 103: 427-34.

  • Gladman MA, Knowles CH. Novel concepts in the diagnosis, pathophysiology and management of idiopathic megabowel. Colorectal Dis 2008; 10: 531-8.

  • Gladman MA, Sayer GL. Chronic constipation secondary to bilateral common iliac artery aneurysms. Gastroenterology 2008; 134: 1294 & 1636.

  • Gladman MA, Mukherjee D. Chest pain and congestive cardiac failure due to atrial metastasis from an adenocarcinoma of the gastroesophageal junction. Gastroenterology 2008; 134: e4-6.

  • Murphy J, Scott SM, Gladman MA, Lunniss PJ. Re: Faecal incontinence. Br J Surg 2007; 94: 754.

  • Gladman MA, Dvorkin LS, Scott SM, Lunniss PJ, Williams NS. A novel technique to identify patients with megarectum. Dis Colon Rectum 2007; 50: 621-629.

  • Gladman MA, Shami SK. Medical mystery: an unusual complication of colonoscopy. New Engl J Medicine 2007; 357: 59.

  • Vasudevan SP, Scott SM, Gladman MA, Lunniss PJ. Rectal hyposensitivity: evaluation of anal sensation in female patients with refractory constipation with and without faecal incontinence. Neurogastroenterol Motil 2007; 19: 660-667.

  • Gladman MA, Shami SK. Medical mystery: an unusual complication of colonoscopy – the answer. New Engl J Medicine 2007; 357: 2309.

  • Gladman MA, Lunniss PJ, Scott SM, Swash M. Rectal hyposensitivity. Am J Gastroenterol 2006; 101: 1140–1151.

  • Ramachandran M, Gladman MA. Maximize YOUR Medical Career. BMJ career focus 2006; 333: 211.

  • Gladman MA, Dvorkin LS, Lunniss PJ, Williams NS, Scott SM. Rectal hyposensitivity: a disorder of the rectal wall or the afferent pathway? An assessment using the barostat. Am J Gastroenterol 2005; 100: 106–114.

  • Brinkmann D, Gladman MA, Norman S, Lawton FG. Why do women still develop cancer of the cervix despite the existence of a National Screening Programme? Eur J Obstet Gynecol Reprod Biol 2005; 119: 123 – 124.

  • Gladman MA, Scott SM, Lunniss PJ, Williams NS. Systematic review of surgical options for idiopathic megarectum and megacolon. Ann Surg 2005; 241: 562-574.

  • Gladman MA, Williams NS, Ogunbiyi OA, Scott SM, Lunniss PJ. Medium-term results of vertical reduction rectoplasty and sigmoid colectomy for idiopathic megarectum. Br J Surg 2005; 92: 624-630.

  • Dvorkin LS, Gladman MA, Epstein J, Scott SM, Williams NS, Lunniss PJ. Rectal Intussusception in Symptomatic Patients is Different from that in Asymptomatic Volunteers. Br J Surg 2005; 92: 866-72.

  • Dvorkin LS, Gladman MA, Scott SM, Williams NS, Lunniss PJ. Rectal Intussusception: A Study of Rectal Biomechanics and Visceroperception. Am J Gastroenterol 2005; 100: 1578-85.

  • Gladman MA, Knowles CH, Gladman LJ, Payne JG. Intraoperative Cultures in Appendicectomy: Traditional Practice Challenged. Ann R Coll Surg Engl 2004; 86: 196-201.

  • Lunniss PJ, Gladman MA, Hetzer F, Williams NS, Scott SM. Risk Factors in Acquired Faecal Incontinence. J R Soc Med 2004; 97: 111-116.

  • Gladman MA, Scott SM, Chan CLH, Williams NS, Lunniss PJ. Rectal Hyposensitivity: The Prevalence and Clinical Impact in Patients with Intractable Constipation and Fecal Incontinence. Dis Colon Rectum 2003; 46: 238-246.

  • Gladman MA, Scott SM, Williams NS, Lunniss PJ. Clinical and Physiological Findings, and Possible Aetiological Factors of Rectal Hyposensitivity. Br J Surg 2003; 90: 860-6.

  • Gladman MA, Scott SM, Lunniss PJ, Williams NS. Re: Strategy for the surgical management of patients with idiopathic megarectum and megacolon. Br J Surg 2002; 89: 623.

  • Gladman MA, Macdonald D, Webster JJ, Cook T, Williams G. Renal Cell Carcinoma in Pregnancy. J R Soc Med 2002; 95: 199-201.

  • Haq AI, Tiwari A, Gladman MA, Mohanna PN. A Simple Technique for Irrigating the Abdomen and Pelvis through an Appendicectomy Wound. Ann R Coll Surg Engl 2002; 84: 211.

  • Gladman MA, Khullar V, Cardozo LD. First Do No Harm: Knowing When Not To Operate. J Obstet Gynaecol 2001; 21: 530.